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The Shot Maker Society- XMD Wellness

The Shot Maker Society
XMD Wellness

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90 Day GLP-1
Roadmap Guide

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GUIDE 3: Your 90-Day GLP-1 Roadmap

What to Expect Physically, Mentally & Metabolically

Starting GLP-1 therapy is not just about appetite suppression or weight loss. It is a metabolic reset process that unfolds over time. Understanding what happens in your body during the first 90 days helps you stay consistent, set realistic expectations, and recognize progress beyond the scale.

This guide walks you through what most clients experience in the first three months, how providers adjust treatment, and why patience matters.

Before You Begin: A Quick Reality Check

GLP-1 therapy is:

  • Not instant

  • Not linear

  • Not the same for everyone

 

Weight loss is one outcome, but the first 90 days are primarily about metabolic adaptation, appetite regulation, and hormone signaling.

Some changes happen quickly; others take time.

What’s Happening in Your Body
 
During the first 1–2 weeks, GLP-1 medications begin interacting with:

  • Appetite signaling centers in the brain

  • Gastric emptying (how quickly food leaves your stomach)

  • Blood sugar regulation

Your body is learning how to respond to new hormonal signals.

Common Experiences

  • Reduced hunger between meals

  • Feeling full sooner

  • Less interest in snacking

  • Decreased food noise (mental chatter around food)

  • Mild nausea or digestive changes (not everyone)


⚠️ Important:
This is not the fat-loss phase yet for many people. Early weight changes may reflect reduced inflammation, glycogen depletion, or digestion changes—not true fat loss.

Weeks 1–2: Appetite Signaling & Early Adjustment

Weeks 3–4: Stabilization & Pattern Recognition

What’s Happening

Your body starts to stabilize its response to the medication. Appetite suppression becomes more predictable, and digestion begins to normalize.

 

What Many Clients Notice:

  • More consistent fullness cues

  • Fewer cravings for highly processed foods

  • Better control over portions without effort

  • Improved awareness of hunger vs habit eating

 

This is when providers evaluate:

  • Tolerance

  • Side effects

  • Whether dose adjustments are needed

 

🔍 This phase is about data, not speed.
Providers use this window to decide how your plan should progress.

What’s Happening

This is when true metabolic changes often begin:

  • Improved insulin sensitivity

  • More efficient fat utilization

  • Reduced inflammation for many clients


What You May Notice:

  • Steady weight loss (not dramatic drops)

  • Clothing fitting differently

  • Decreased bloating

  • More stable energy levels

  • Improved relationship with food


Some clients see the scale move slowly here — that’s normal. Body recomposition often precedes scale changes.

Weeks 5–8: Metabolic Engagement & Visible Change

Weeks 9–12: Momentum
& Habit Integration

What’s Happening

By this point, GLP-1 therapy is no longer “new” to your body. Appetite signals, digestion, and metabolic responses are working together more efficiently.

 

What Progress Often Looks Like:

  • Predictable appetite control

  • Fewer emotional eating episodes

  • Consistent weight trends

  • Improved confidence in food choices

  • Easier adherence to nutrition habits

 

This is when long-term success starts being built, not because of willpower — but because biology is finally supporting behavior.

Micro-Dose Clients Often Experience:

  • Slower, steadier changes

  • Minimal side effects

  • Appetite control without strong suppression

  • Gradual weight loss over time


Macro-Dose Clients Often Experience:

  • Stronger appetite suppression earlier

  • Faster initial weight loss

  • More noticeable metabolic changes

  • Closer provider monitoring


Neither approach is “better.” The goal is the right dose for your body and goals.

Micro-Dose vs Macro-Dose: How the 90 Days May Differ

Why the Scale Isn’t the Only Metric

During the first 90 days, progress may show up as:

  • Reduced inflammation

  • Better blood sugar control

  • Improved digestion

  • Less joint pain

  • Better sleep

  • Reduced food obsession

 

These changes often happen before significant scale movement.

🚫 Expecting immediate dramatic weight loss
🚫 Under-eating due to low appetite
🚫 Comparing progress to others
🚫 Skipping protein and hydration
🚫 Stopping too early

 

GLP-1 therapy works best when paired with patience, nourishment, and consistency.

Common Mistakes in the First 90 Days

What Providers Are Monitoring During This Time

Licensed providers evaluate:

  • Appetite response

  • Side effect tolerance

  • Weight trends

  • Metabolic markers (when applicable)

  • Overall wellbeing


Adjustments are made based on your response, not a preset schedule.

The first 90 days are not about perfection.
They are about setting the foundation for sustainable weight loss, metabolic health, and long-term success.

Most clients who stay consistent through this phase see:

  • Better outcomes

  • Fewer setbacks

  • Easier maintenance later

The Big Picture

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